Characterization of a Human Glutathione S-Transferase m Cluster Containing a Duplicated GSTM1 Gene that Causes Ultrarapid Enzyme Activity
نویسندگان
چکیده
Division of Molecular Toxicology (R.A.M., M.O., M.I.-S.) and Unit of Genetic Toxicology (A.-K.A., A.R.), Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden, National Institute for Working Life, 171 84 Solna, Sweden (A.-K.A., A.R.), The Wallenberg Laboratory and Astra Draco AB, 221 00 Lund, Sweden (J.S.), and C 123 Riyadh Armed Forces Hospital, Riyadh 11159, Kingdom of Saudi Arabia (D.A.P.E.)
منابع مشابه
Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity.
The mu class glutathione S-transferase gene GSTM1 is polymorphic in humans, with approximately half of the Caucasian population being homozygous deleted for this gene. GSTM1 enzyme deficiency has been suggested to predispose people to lung and bladder cancer. Some people in a Saudi Arabian population, however, have been described previously with ultrarapid GSTM1 enzyme activity. Here we have ev...
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